NMFC 59225 - Prescription Drug Samples in Boxes | Class 200

Note 59226: NOTE-Applies on sample units consisting of a packet, card, blister pack, bottle, container, or other single package comprised of one or more dosage units of a prescription drug sample intended by the manufacturer or distributor to be provided by a licensed practitioner to a patient in an unbroken or unopened condition.

To find the correct freight class for your shipment:

1. Verify the items meet 21 CFR 203.3 as drug samples and are packed in boxes. If not true samples or not boxed, review related items 58772 or 59226 before booking.
2. Use rigid cartons with inner cushioning and tamper‑evident seals. Mark cartons “Drug Sample – Not For Sale,” and keep NDC, lot, and expiry visible on a packing list inside.
3. On the BOL, describe as “Prescription Drug Samples, NMFC 59225, Class 200, Non‑Haz.” Include consignee license details if required by your compliance team and request appointment delivery for clinics.
4. If temperature control is needed, place insulated shippers and gel packs inside the outer box. The NMFC remains Class 200; note any time‑sensitive or cold‑chain handling instructions for the carrier.

Note: All classifications are subject to Item 170. Verify with official NMFC publications for the most current requirements.

• Predictable costs with fixed Class 200 rating, minimizing reclass or density disputes and making LTL quotes more reliable.
• Non‑hazardous status broadens carrier options and helps avoid hazmat surcharges, documentation, and transit delays.
• Regulatory alignment with 21 CFR 203.3 reduces risk of carrier refusals and compliance issues when delivering to licensed practitioners.
• Boxed packaging streamlines dock handling, improving claim outcomes through better carton protection and clear sample labeling.